prevalence of antiphospholipid antibodies in syrian patients with thrombosis
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abstract
background: antiphospholipid antibodies (apl) are a heterogeneous family of anti-bodies associated with thrombosis and other complications. objective: to study the prevalence of apl in patients with thrombosis at aleppo university hospitals, syria. methods: one hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. anticardiolipin antibodies (acl) and lupus antico-agulant (la) were determined. results: thirty-four out of 157 (21.7%) patients with thrombosis had some type of apl. apl was also found in four healthy subjects (4/63=6.3%). eighteen patients (11.5%) were positive for la, 20 (12.7%) for acl anti-bodies and 4 (2.6%) were positive for more than one apl. patients without risk factors for thrombosis and having positive apl were 23/34 (67.7%). fourteen out of 78 (17.9%) patients with arterial thrombosis, and 20/79 (25.3%) with venous thrombosis were positive for at least one apl. conclusion: our study showed a significant preva-lence of apl in patients with thrombosis. it seems that apl is a risk factor for venous and arterial thrombosis, especially in patients with no conventional risk factors.
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Journal title:
iranian journal of immunologyجلد ۶، شماره ۳، صفحات ۱۵۴-۱۵۹
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